Thứ Sáu, 30 tháng 3, 2018

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imagine the sound of fingernails scrapping across a blackboard if you are

like most people then you probably can't stand that kind of sound and even just

thinking about it might be making your skin crawl and don't worry we are

definitely not going to play that kind of sound in this video

there have been number of studies to find out why this ear piercing noise is

universally disliked and receives such a non-rational reaction a study published

in the Journal of Neuroscience in 2012 reveals what's happening in the brain

when people hear screechy sounds in the study 13 participants listen to 74

sounds and rated them from the most unpleasant which is of the sound of a

knife on the bottle to the most pleasing which is of babbling water brain imaging

of the participant shows that when they heard an unpleasant noise the amygdala

active in processing emotions adjust the response of the auditory cortex part

of the brain that processes sound which heightens activity and triggers the

negative emotional reaction doctors Sukhbinder Kumar a research

fellow at Newcastle University said it appears there is something very

primitive kicking in it's a possible distress signal from the amygdala to the

auditory cortex the acoustic analysis found that anything in the frequency

range of around 2,000 to 5,000 Hertz was perceived as unpleasant this is the

frequency range where our ears are most sensitive it includes sounds of screams

which we find highly unpleasant overall the research shows that this kind of

noise has the same frequency as that of human scream and a crying baby

indicating that these sounds are tied to survival researchers also found that the

warning cry of a chimpanzee is similar to the sound of fingernails on a

chalkboard perhaps people have an unconscious reflex to this sound because

of its uncanny resemblance to a warning call now what is the purpose of this

research? of course we are curious and want to

know the answer to everything but is there anything other than that behind

this research? well yeah! this research is an important step forward in undertaking

and helping to treat conditions that make people sensitive to certain sounds

such as tinnitus, migraine headaches, or autism well now at least we have some

idea as to why this kind of noise evokes such a visceral reaction and why getting

a proper answer to this question is so important for researchers

For more infomation >> Why Do Some Sounds Make us Cringe? - Duration: 2:50.

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Why Do Realtors Take Overpriced Listings? - Duration: 3:22.

Hi everyone. This is your Tampa Bay Realtor Lance Mohr and in this video I

want to talk about a question I've been getting for years since I've been in the

business over 20 years ago and that is why do Realtor's take over priced

listings that's what I'm going to talk about in the short video

now I'm a little surprised I haven't done a video on this because I just had

so many people ask me neighbors asked me I mean just friends acquaintances

everybody why'd a realtor's takeover price listings and a lot of people don't

really understand and know why so let me just give you a few reasons why

realtor's me take over price listings the first one is they just think if the

seller has to get the home sold they might as well be the person that lists

it I had an agent told me one time he said Lance what was I supposed to do if

the sellers going to list the home at least it's me at the end of the day

he'll eventually sell it and I'll get paid money so I don't necessarily agree

with that right there I think you should be always be up for an honest with

someone but as long as they are then you know you're gonna have to make the

decision as a seller another one is that just the pressure of the office in real

estate they always say listings listings listings the office is pretty much

everywhere any books you read you know any any type of training we go to

everything's just about listings listings listings and of course the

office wants the art sign in the front yard they want the the recognition they

want to be seen and a lot of times the agent does too they want the sign in the

yard maybe they wanted in the art so they can knock on doors and see if

anybody else wants to sell or they could call on the telephone to the

neighborhood hey I have a listing or you thinking of lists in your home another

reason they may want to do it is maybe they want to sit open houses it's a very

passive way to sell a home but open houses were never it was never really

meant to sell homes from the real estate community most agents do it in virtually

all agents do open houses because they're trying to procure a buyer

they're trying to get a buyer that they could work with they're basically using

the property as a marketing tool and how buyers come in and they need buyers so

that that's so that's the way as well there's a lot of different reasons why

agents may take over priceless seeds those are the some of the most common

reasons now I said this a lot over the years if you've got to hire a real

estate agent hi based off of their marketing and hyerim

based off of their negotiating skills if you have any questions whatsoever don't

hesitate to contact me if you know anybody looking at buying a home or

selling a home share my videos with them hopefully the videos will help them out

I appreciate you watching my videos if you have any questions or concerns don't

hesitate to give me a call I'd love to answer your questions or if you're in

the Tampa Bay area or you're looking for a good aggressive agent to list your

home and sell it let me know as well take care and thank you

you

For more infomation >> Why Do Realtors Take Overpriced Listings? - Duration: 3:22.

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13 Reasons Why • "Why would a dead girl lie?" - Duration: 2:11.

That was the first time I've ever lied to either of them.

Welcome to the dark side.

See, I've heard so many stories about me now that I don't know which one is the most popular.

What did you do?

I-I talked to Tyler this morning...

Is this all of them?

Yeah.

He told me he got rid of all of them!

Well, he lied.

But I do know which is the least popular.

What are you doing?

The truth.

I thought you were easy.

What my intel's no good?

No... It's not good.

We kissed...

That's all that happened.

Why?

What the fuck, Courtney?

Did you hear something else?

Yeah, everyone already thinks she's a slut, so why not just pile on?

Don't believe everything you hear.

Why would a dead girl lie?

I had nothing to do with this!

She's the one who ended our friendship, and she knew it.

Fuck you!

She's a liar.

Is Hannah telling the truth?

If you wanna know the truth

just press play.

Hannah's a user and a liar and you can't believe anything that she says.

Sooner or later people are going to find out.

People are not...

gonna fine out.

We all know the story.

Everything Hannah said on the tapes is true.

Hannah's truth is not my truth...

No way.

You know

what's true?

I do now.

It's about protecting ourselves.

From what?

From Hannah's lies!

But did she lie?

Because she told the truth about me.

That night did not happen the way Hannah said it did.

Hannah was a liar.

She was jealous

and needy

and emotionally unstable.

If Hannah had seen something she would have told me...

Right?

We both know she just made all that stuff up.

So whatever Hannah thought she saw

she lied about it on those tapes

because she's a crazy fucking drama queen

who just killed herself for attention!

Because that photo of her on the slide with Justin was real...

The hot or not list was real so...

You've all been staring at my ass all day.

Maybe the rest was too?

See the truth isn't always the most exciting version of things.

But it deserves to be heard and remembered.

Hannah was my friend...

we should tell the truth about her.

Because everyone is just so nice until they drive you to kill yourself!

And sooner or later the truth will come out.

It's gonna come out.

For more infomation >> 13 Reasons Why • "Why would a dead girl lie?" - Duration: 2:11.

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Why Do we fail - MOST INSPIRATIONAL VIDEO EVER - Duration: 10:51.

I didn't have any money so I had no phone I painted my windows black so I

didn't know if the sun was up or the Sun was down all I knew is I had to write and I

wrote it wasn't good at all but every day it was getting better and better

like like a machine like a muscle until finally the idea for rocky came

so the idea is you must fail a hundred times to succeed once, that's part of it

No one succeeds the first time it's learning how to not get disappointed

with failure to understand failure you only learn when you fail

you don't learn when you succeed but when you fail that's where you learn so that's how I learned

I was a failure in New York and that is the reason I started writing

which made me successful

I think everybody has fear all wrong people have so many theories about fear

they talk about, I'm afraid of success, I'm afraid of failure I'm

afraid of intimacy I'm afraid of heights I'm afraid of this I'm afraid of that

I'm afraid of the other thing there's actually only two fears only two

life is persuading people life is about influencing people and fear is the

invisible force that will make you ineffective at that it will stop you now

I love JK Rollins as an example I mean we all know the Harry Potter series but

what a lot of people don't know about her she talks a lot about fear she

struggled with major depression do you know she was unemployed and she wrote

the original idea for Harry Potter on a napkin while she was on state benefits

she was then rejected by 12 publishing houses and this by the way was after she

was divorced bankrupt and a single mom of a kid

pushed herself, pushed herself, pushed herself

she talks a lot about fear and about failure

well you know we know the moral of the story

She kept Going, of course she was afraid, but

she had the good kind of fear not the bad kind of fear

There is another level

the only reason you keep saying there isn't is you feel so exhausted about where you are

but life the universe or God is just testing you because there is another level

there's a level where all your dreams are realized

There is a level that you have always dreamed about, it is real

it is not gone away, but it takes that extra burst when you

think there's nothing left, there's no way you tried everything ten million times

and you keep going, it's almost like God is saying if you keep hitting

this wall enough times i will, i will see that you will not stop that you will fill

that level of determination, faith and courage and the door opens and you get to that next level

but what most people don't know is the next level is just 2mm above

and it's called Outstanding

ladies and gentlemen outstanding

Outstanding, magnificent, unstoppable, extraordinary, not excellent

Its a different level it's a level where you are not one of the best you are the best

you know what's amazing you only have to be 2mm more than everybody

else and you get everything you get the joy the laughter the fun the family

the passion, the economics, the freedom, the spirit it's all there

what Jerry Maguire called the quan baby all of it and it's just 2mm above

and most excellent people give up because they're exhausted and there's

some people go the harder I hit it the more I hit it sooner or later it's going

down I'm not stopping and when you do that enough it pops open

in a world that's changing so quickly the biggest risk you can take is not taking any risk

and I really think that that's true right a lot of people I think think that

you know whenever you get yourself into a position where

you have to make some some big shift and direction or do something you know there

are always people are going to point to the downside risks of that decision and

locally they may be right where I mean if for any given decision that you're

gonna make there's upside a downside but in aggregate if you are stagnant and you

don't make those changes then then I think you're guaranteed to fail

right and not not catch up so to some degree I think it's really right that

over time the biggest risk that you can take is to not take any risks

failure is a part of the learning process right what's the risk of failure what you'll

be embarrassed or risk of failing how do you distinguish failure from learning

get in your whole life you know failure implies that it stopped that the game

stops right if it's part of it you're failing and then you learn

is part of the moving forward right so that is what the process is like fail

learn move forward and constantly do that because you're cutting edge you're

going where people haven't been before in inventiveness

through all the occupations I've had I've experienced successes

and as you know failures I'm asked what it

felt like to lose to President Obama not as good as winning, failures aren't fun

but they are inevitable more importantly failures don't define who you are

some people measure their life by their secular successes how high on the

corporate ladder they got how much money they made did they do better than their

high school classmates if that's the kind of success you're looking for

you're bound to be disappointed life has way too much chance in serendipity to be

assured fame or fortune

You cannot achieve success without failure, some of

my biggest successes come from some of my biggest failures

in the early 90s when my friends were graduating from Howard I got fired from

that first job that I got with Andre harrell

I know a lot of you know this story but some of you may not know how scared I was

see I was scared to death I didn't have a degree

My girlfriend was 8 and a half months pregnant

with my first baby, I bought a brand new house in Scarsdale that I

could not afford so I found myself sitting alone in my

bedroom and asking myself the question

And sometimes we all ask each other

what are you going to now?

what are you going to now?

you should've kept your mouth shut, shut up and just did what Andre told you to do but

you wanted to act like you was making the hit records now look at you what are

you gonna do now, so I had two choices either I was gonna sit in that failure

and give up or I was gonna make a decision to step out of the darkness you

see when you're in that darkness you want to sit there and wait for the light

to come when you're in that darkness it feels uncomfortable but you can't wait

and sit in that darkness the only way out is to step forward to face your

fears to become your own lightning I had to make a decision I had to decide to

become my own light I had to believe in myself like never before I had to find

my inner power now I'm not gonna lie to you there's

gonna be a lot of times y'all about to fail I'm still failing everyday

we are all a work in progress and one day you'll be sitting in the dark like I was

And you're going to be asking yourself what am I going to do now

What am I going to do Now?

But in that moment I want you to remember the power of you

Now here's an important point nothing works the first time when you try

something new it probably won't work when you try something new several times

it probably won't work and the turning point in my life came when I would hear

good ideas and I was so eager to be successful in selling I would run out

and try the ideas and they wouldn't work I try a way of getting an appointment or

or answering an objection or closing a sale it wouldn't work and my natural

response was ah and I think this has to be disappointing and then I realized nothing

works at least the first few times so I decided I would try a new idea five or

ten times before I pass judgment on I would not just try it once and quit like

most people do and that changed my whole life

it was a turning point in my life because I realized from then on if

you've got a good idea and you've got a good goal and you want to double your

income and improve the quality of your life and you have to try new things in

order to get new results it's not going to work the first time so say well that

didn't work try something else and try something else and try something else

now if you try only two things can happen what are they succeed or fail if

you succeed you do more of it if you fail you learn from it get smarter and

try it again so you cannot lose by taking action you can only lose by not

taking action

if I ever hear my kids say the word

failure I'd lock them in a room for a week I would request if we have any

power in this country that we could take that out of our English dictionary and

replace it with the word feedback because that's all failure in our words

is , isn't it, its feedback, we learn from mistakes

For more infomation >> Why Do we fail - MOST INSPIRATIONAL VIDEO EVER - Duration: 10:51.

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Why Do I Feel Sick in the Car? - Duration: 4:28.

[ INTRO ]

Squeaks and I are going on a road trip!

We're off to see the Grand Canyon, a set of huge cliffs in Arizona, in the United States.

[Squeaks is excited]

Squeaks is so excited!

But, there's one problem: he doesn't feel so good when he's riding in a car.

He gets carsick!

Getting carsick is a type of motion sickness — when being in something moving, like a

car, makes you not feel well.

People can also get motion sickness on a boat, or a plane, or even on a roller coaster.

If you get motion sickness, you might feel nauseous, like you're about to throw up.

You might also feel dizzy, sweaty, headache-y, tired, and generally pretty crummy.

One weird thing about motion sickness is that some people get it and some people don't.

Kids tend to get motion sickness more than adults, so if you have it now, you might not

have it when you're older, or at least it might not be as bad.

But in the meantime, there are some ways to help yourself feel a little better.

It all has to do with what causes motion sickness in the first place.

Think about what's happening when you're riding in a car:

You're sitting still, because you're inside a car, but the car is moving … so you're

also moving!

And that can get your brain kind of mixed up.

Your eyes tell your brain that you're sitting still inside the car, you're buckled in,

and you're definitely not running or even walking.

So based on what your eyes are seeing, your brain thinks you're sitting still.

But in the meantime, your ears are telling your brain something totally different.

And I don't mean because of what you're hearing, because your ears do more than just

hear.

Your inner ear, a tiny but very important part of your body deep inside your ear, keeps

track of how your body moves around.

And it can tell that you're moving.

Way inside your ear there are three little tubes, and inside each tube is a little bit

of liquid and tiny little hairs.

And when you move, so do the liquid and hairs!

You can imagine the liquid in your ear like this glass of water.

When I tilt the glass to the side, the water tilts, too.

If you tilt your head, the same thing happens to the liquid inside your ear, which is how

your brain knows that you moved your head.

Now check out what happens when I quickly slide the glass across the table.

See how the water sloshes to one side of the glass?

Well, when you're in a car that zooms forward, the same thing happens to the liquid in your

ear.

So that's how your ears know you're moving even though you're sitting still inside

the car!

If you get motion sickness, that's because your brain does not like getting these different

messages.

And that's why you might feel nauseous and dizzy and overall really yucky.

We still aren't totally sure why getting those different signals causes nausea.

But some scientists think it's because your brain thinks all the weird mixed signals are

being caused by something that made you sick, like poison.

So, your brain tells your body to throw up to get the poison out … even though there

isn't really any poison!

Anyway, back to Squeaks here.

He's a little worried about our road trip since he gets motion sickness, but if you

get carsick, there are some things you can do to feel better!

First, you can eat a light meal before going on a trip — not too much, and not too little.

Basically, you want to keep your stomach happy so you aren't encouraging any nausea.

Then, once you're in the car, looking out the window can help a lot.

Scientists say to look at the horizon, which is the line where the sky meets the land or

the road.

That way your eyes can tell exactly how you're moving compared to the world around you.

If both your eyes and your inner ear agree that you're moving, there are no more confusing

messages … which means that hopefully you'll feel better.

For the same reason, it's better not to read a book or play games on a tablet or phone

while you're in the car.

If you're staring at something right in front of you inside the car, that makes it

look like you're staying still, which can make you feel worse!

Looking out the window can be way more interesting, anyway.

You can look at the trees, the sky, the road signs, and the other cars zooming by!

It can also be really relaxing, which is awesome because staying calm and relaxed can help

you avoid motion sickness, too!

So, Squeaks and I are going to eat a light lunch, since some food in your stomach really

helps prevent motion sickness.

And after that, we're off on our super-exciting road trip to the Grand Canyon!

But we'll be back at the Fort soon!

Thanks for joining us!

If you want to keep learning and having fun with Squeaks and me, hit the subscribe button,

and we'll see you next time here at the Fort!

[ OUTRO ]

For more infomation >> Why Do I Feel Sick in the Car? - Duration: 4:28.

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Why Is It So Hard to Make a Male Birth Control Pill? - Duration: 5:35.

[♪ INTRO ]

At a meeting of endocrinologists this month, researchers presented new work that suggests

they're one step closer to a male birth control pill!

Do you feel like you've heard this news before?

Well, that's probably because you have.

Scientists have been looking into a safe, reversible kind of male birth control for

decades and they've gotten close, but not quite there.

Even here on SciShow, we've reported on things like chromatin remodeling, hormone

injections, and a dissolvable gel that plugs up the vas deferens — AKA the sperm tubes.

Researchers call these treatments "male birth control" for short, because they're

tested in cisgender males who are making sperm.

So why's it so tricky to make a male pill?

The short answer is: it's a lot easier to stop one egg a month than millions of sperm

a day.

The female birth control pill has been around since 1960 — nearly 60 years ago!

And it's one of many options out there.

The pill has synthetic hormones — either a combination of estrogen and progestin, or

progestin alone.

So it stabilizes hormone levels and prevents the spike in estrogen that normally happens

midway through the menstrual cycle, setting off a chain of events that lead to ovulation.

Without that spike, no egg is released and no babies are made.

Very rarely, the female birth control pill can have serious side effects, like blood

clots or heart problems.

But it has some potential health benefits too, like reducing bone thinning, anemia,

or risk of some cancers.

Other than condoms, vasectomies, and withdrawal… there aren't many male birth control options.

And nothing based on hormones has panned out.

On average, men release around 180 million sperm every time they ejaculate.

It only takes one to fertilize an egg and get their partner pregnant.

So… that's a lot of sperm to deal with.

Instead of physically stopping them, like a condom does, male pills aim to lower the

sperm count.

Basically, stopping the production of sperm cells, but leaving the rest of the semen alone.

And the basic strategy for this is kind of counterintuitive.

It turns out that if you give men lots of testosterone, they stop making sperm.

Sperm are produced in the testes, which are also testosterone factories.

So testosterone levels are really high in there, like 25-125 times higher than in blood.

And sperm need those high concentrations of testosterone to develop correctly.

But when a dude gets an injection or a pill of extra testosterone, the brain and pituitary

gland sense that body-wide levels are high enough and shut off production in the testes.

With no testosterone being made down there, the concentration drops, and sperm don't

develop.

Previous attempts at male hormonal contraception involved weekly or monthly doses of synthetic

testosterone.

And if you add progestin, these injections, implants, or patches worked even better.

But even though they were good at stopping sperm production, there were drawbacks.

It was difficult to get synchronized, steady levels of testosterone and progestin.

And weekly, or even monthly, injections aren't as convenient as a daily pill you can take

at home.

Birth control doesn't work if you can't get people to use it.

Plus, some men had unpleasant side effects like pain at the injection site, acne, or

changes in mood including more aggression.

Researchers were wary of giving the necessary big doses of oral testosterone, too, because

previous studies have shown that this can be really hard on the liver.

Not to mention, the body clears this orally-delivered testosterone pretty quickly so pills have

to be taken twice a day.

So what makes this new male pill different?

This research is a team effort from scientists at the University of Washington and the Los

Angeles Biomedical Research Institute.

And they presented their work at the recent Endocrine Society meeting in Chicago.

Their experiments focused on a compound called dimethandrolone undecanoate or DMAU.

It has a different structure than testosterone that lets it hang around in the body longer,

which keeps levels steady even if it's only taken once a day.

DMAU is considered a pro-drug, because it's converted to an active molecule that interacts

with the body after it's ingested.

In this case, enzymes called esterases change DMAU into dimethandrolone or DMA.

And DMA binds to the same hormone receptors as testosterone and progestin throughout the

body.

Just like testosterone given in a pill or injection, DMA tricks the body into producing

less testosterone in the testes, so concentrations there drop and sperm aren't produced.

When the researchers tested this in animals it worked pretty well.

It even stopped sperm production in rabbits, who have legendary fertility.

Sounds promising, right?

This research is getting a lot of attention, but it's still in the early stages.

Here's how the recent experiment went down: researchers had 83 men between ages 18 and

50 take DMAU pills daily for 28 days.

They also took blood samples before and after, to check for hormone levels and other health

markers like cholesterol.

And the scientists found that the testosterone in the participants' blood decreased to

very low levels — levels that suggested that sperm production was effectively shut

down.

Now, it's important to note though that they didn't actually measure sperm count.

This study was mostly to test whether the pill is safe.

And it seems like it is!

The participants didn't report any significant changes in sex drive, sexual function, or

any serious side effects with their livers or kidneys, which were all potential concerns.

Some men had mild weight gain and increased red blood cell count.

And some had slightly decreased levels of the good form of cholesterol, but these weren't

serious problems.

The research team is starting another study soon that will follow men taking the DMAU

pill for a longer period of time, and take semen samples to measure their sperm production.

So whether it's this team or another than makes the breakthrough... safe, convenient,

reversible male birth control will definitely be a pretty big deal.

And you know who else is a big deal?

SR Foxley, our SciShow President of Space.

He's actually pretty humble, but he's a big deal to us because he helps make SciShow

possible every month so we can bring you the latest in science news and dig deep into big

questions.

Thanks SR!

You are the best!

And to learn more about how you can help us out too, check out patreon.com/scishow.

[♪ OUTRO ]

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