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(peaceful music)

- [Megan] I think there's a strong emotional connection

to lakes by Minnesotans

because it's really a big part of our identity

and we all want to protect that for future generations.

- So much of Minnesota's culture

and recreation is based around the water

and enjoying our lakes and rivers.

So aquatic invasive species and other threats

to those habitats really affect people personally.

I'm Dan Larkin.

- And I'm Megan Weber and we're protecting Minnesota's

life at the lake.

(water splashing)

(upbeat music)

There's over 13 million surface acres of water in Minnesota.

- [Dan] That's a lot of water to cover.

- [Megan] And a real limited number

of paid professionals to do aquatic invasive species work.

The AIS Detectors program was started by

the Minnesota Aquatic Invasive Species Research Center

in partnership with the University of Minnesota extension.

We work to develop a training program for our volunteers

and then have worked with Minnesota DNR

to help review that training.

- [Dan] Got some Utricularia here.

- [Megan] Oh yeah.

- Minnesota's lakes, rivers and streams are at risk

from a variety of aquatic invasive species,

including invasive fish,

invasive plants and invasive invertebrates.

Aquatic invasive species are a major issue,

and we're developing programs like AIS Detectors

to increase capacity of everyday Minnesotans

to get involved in responding to this challenge.

Basically give them the training and education to be

eyes on the water and increasing our capacity

for early detection.

(boat motor)

(soft music)

- We are on the shores of Turtle Lake

in north Itasca County.

We were drawn to the AIS Detector program

because we thought it would be a good way to get involved

in doing things to help protect our lake

and spend more time together.

What we do is we talk together about

which parts of the lake shore we wanna do a survey on

and we will go to that section of the shoreline

and then we'll go back there about a month later

and at that time we're looking for a change.

And one of our goals was to educate and reach out to a lot

of the people around us to help keep those species

from spreading to these pristine waters.

- The way we're implementing a prevention program,

it's primarily focused on the local community.

We meet people who once they hear what we're doing say,

"Oh, we wanna join you."

So this work is definitely making a difference.

- That's another way that the AIS Detectors program

is really important is it provides people with local experts

to talk about aquatic invasive species issues.

- The AIS Detectors program has had

a really good response so far.

We've completed two years of training

and we have over 200 people who have passed the course

and are now contributing volunteer hours.

- The way we look at this is, this is our lake,

and this is our legacy.

(playful music)

For more infomation >> Our Lake, Our Legacy: protecting Minnesota's life at the lake - Duration: 3:53.

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Bringing Discovery to Minnesota's Doorstep - Duration: 1:01.

(upbeat music playing)

You know the University of Minnesota, but do you really know what the U of M does for you?

How these U of M ecologists are enlisting everyday Minnesotans

to fight invasive species?

Or how these educators are helping our farmers become even more successful?

Join us as we take you on a journey across this great state

to show how our daily discoveries affect your daily life.

From a grassroots attack on the opioid epidemic,

to using a robot for earlier autism detection.

From her rural retail revitalization,

to his major breakthrough in cancer treatment.

We'll share the stories that bring the drive to discover

straight home to Minnesota's doorstep.

Take discovery to the next degree.

For more infomation >> Bringing Discovery to Minnesota's Doorstep - Duration: 1:01.

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The State of Agriculture and Challenges Facing Minnesota Farmers - Duration: 28:31.

For more infomation >> The State of Agriculture and Challenges Facing Minnesota Farmers - Duration: 28:31.

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Sleeping Beauty, Sleeping Giant: a breakthrough treatment in the fight against cancer - Duration: 4:59.

- [Perry] The greatest advances made in science

I believe have all been based on serendipity.

30 years ago, Governor Perpich wondered

whether or not there was some way to restore Minnesota lakes

to their prior luster as fishing destinations.

My lab was working on cancer viruses

and someone asked me whether or not I could help them

with genetically engineering fish

and in the process we found an element in fish

that was resurrected to become a primary way

of fighting cancer after a 14 million year genetic sleep.

We call it "Sleeping Beauty".

I'm Perry Hackett and this is

the best Minnesota fishing story you've ever heard.

(upbeat classical music)

At the beginning of the 21 century

was the idea that it might be possible

to reprogram a person's immune cells

to be directed to attack and kill specific types of cancer.

CAR T-cell therapies began using viruses

to bring the DNA in.

They were so efficacious that two therapies

were approved by the FDA for the general population.

The problem is that roughly only 10% of patients

that would qualify for this therapy can actually get it.

After we brought the Sleeping Beauty back to life,

my colleague, Scott McIvor, suggested that

it could be used for non-viral gene therapy.

Then Lawrence Cooper spent 10 years

developing the Sleeping Beauty system to reprogram T-cells

and that unlocked efficient human gene therapy

that didn't involve viruses.

No one had thought about that before we did it.

The Sleeping Beauty transposon system

has matched the results of the viral studies.

And there are reasons to believe that Sleeping Beauty

may be preferable, not only for price and availability,

but also for potential effects.

(dramatic piano)

- I think you can think of biotechnology in particular

as sort of two approaches.

You can either take the approach

where you want to hoard the technology and own everything,

or you can take an abundance mentality view

that as you share it, it will have a broader impact.

The University of Minnesota with

the Sleeping Beauty transposon took the view

that the more people that used it,

the greater the chance that it would

have an impact on the world.

And because of that combination of a technology

and a visionary, in this case Perry,

really pushing that this could be something

that could dramatically change a lot of people's lives

that origin led to a whole series of scientists

and they're coming to Minnesota for that.

And that secondary wave is now generating

Minnesota as the destination for genome engineering

because there's a cluster of entrepreneurship expertise.

Globally, Minnesota has the highest density of

genome engineering companies in the world.

What we've been doing, especially the last 20 years,

is building our tool box.

Building the ability to manipulate and alter DNA.

The goal is to master the skills

just like you can with a word processor and change the code.

We're trying to get to the point

where we can do that same thing with DNA

so that we can be able to customize those therapies

based on what your health need is

and as we get better and better

at being able to do this kind of editing,

we're better and better able to

make these kind of custom therapies.

And so it opens up an entirely new concept

in how you're gonna treat health,

all because of Sleeping Beauty

and Perry's vision to share.

It's very important.

- [Perry] Winston Churchill said that people go through life

constantly stumbling over opportunities,

when they do, they pick themselves up,

dust themselves off, and go right along.

But in science, every now and then,

you see something that's a little bit unexpected

or someone asks you a question

and it can redirect your whole scientific career.

So if you stumble over opportunity, don't get up too fast,

look down and see what you stumbled across

because there might be something really important there.

(upbeat marching band music)

For more infomation >> Sleeping Beauty, Sleeping Giant: a breakthrough treatment in the fight against cancer - Duration: 4:59.

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Minnesota Court Of Appeals To Hear Oral Arguments In Brainerd - Duration: 0:47.

NUMBER REQUESTED DURING THE SAME

TIME PERIOD IN THE LAST MIDTERM

ELECTION IN 2014.

>>> A THREE-JUDGE PANEL IN THE

MINNESOTA COURT OF APPEALS WILL

HEAR ORAL ARGUMENTS IN SEVERAL

CASES IN BRAINERD ON THUS

OCTOBER 4th.

THE ARGUMENTS WILL BE OPEN TO

THE PUBLIC AND HELD AT THE CROW

WING COUNTY JUDICIAL CENTER IN

DOWNTOWN BARNED BEGINNING AT

9:30 A.M.

FOR MORE INFORMATION ABOUT THE

MINNESOTA COURT OF APPEAL,

INCLUDING A LIST OF ORAL

ARGUMENTS, THE COURT WILL HEAR