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The musical does not let down. It gets all the gems, all the one-liners from the

movie, are put in there, you know, for the fans, but then, there's a couple twists

you wouldn't expect, a couple little new rewrites and interesting storyline

changes that'll keep people intrigued and entertained. I think that they're gonna

love it.

Well, it's cool to see, like, they're gonna be like, "what's a pager" and

like, "What's a flip phone, what is that?" so it's good to get, like, what we went

through growing up.

I think that everybody can kind of fall in love with

it in a new way. If you are a huge die-hard fan of the original, we have

all of the classics, we got your favorite lines, we have your favorite characters,

we're hitting the costumes, and then we're also putting our own twist on it.

Everyone's version of their character, no one's going for the original way that

it was presented. Everyone's able to put their own spin on it and I think that new

people that haven't seen this before are gonna have to go back and

see the original, and I think it'll be a nice melding of the two.

I definitely

think that it's funny and energetic and that people who have seen the movie will

definitely love it, and anybody who lived through the 90s is gonna like, lose their

minds because it is such a great reminiscing experience.

There's a

beautiful heart to this show that I think people are gonna really fall in

love with. There's a reason why this movie has lasted for so long, and the

musical absolutely carries on that tradition and brings it to a new

audience, a younger audience, fresh ears, fresh eyes and the music that we're

doing... I mean, I get to sing some of the greatest, like, 90s hits that I would sing

in the car when I was a kid, you know, driving down with my friends, and to get

to sing those on stage... it's a dream come true, it's amazing.

I think we do a

really good job of, like, satisfying both. Because you don't have to have seen the

movie, you don't have to come in with any point of context other than wanting to

have a good night of theater. And you will have a good night of theater but if

you want to see Clueless on stage too, you'll have that. We got both, you know?

I think that we have done, so far, a really good job putting what the

longtime fans of Clueless the movie, I feel like we've translated that really

well to the stage, so I think that they're gonna be really excited. I hadn't

even thought about the fact that this will be some people's first experience

with Clueless, and I think that, not only are they going to love this story, but

it's just gonna make them want to go home and watch the movie.

I think if you

love the movie, you'll, like, 100% be obsessed with the musical. Amy Heckerling

is involved in the process, so it is the movie, like, on stage, which I feel like is

fun, and it's a 90s throwback musical, which everybody can, like, love and enjoy,

It hints at the original, but it's also very new, and I think the 90s songs that

are in it will also, I feel like they're gonna blow their minds with like, you

know, when you hear that song you're like, "Oh, no way! That song is in the show?" and

I think that's gonna really win over the crowd.

If they've come to the show

already being a fan of Clueless, they're gonna get a next level of enjoyment and

understanding of this movie that I'm sure they've grown up knowing and loving.

For more infomation >> What will people experience when they see Clueless the Musical? - Duration: 3:10.

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First In Human EP1 (6/6) | What is a CAR T Cell? - Duration: 8:22.

So you are getting at just one arm?

Both of my arms.

Oh wow.

For most patients with acute lymphoblastic leukemia, the kind of cancer Bo Cooper suffers

from, standard treatment can offer a cure.

But Bo is among a very small group whose leukemia has proven incurable.

Back in Canada, Bo received chemotherapy, standard initial treatment, for leukemia.

He then received a bone marrow transplant

and none of those treatments have been able

to keep the leukemia away.

Hey Doc.

How are you doing?

Good.

Yeah?

I'd shake your hand, but there is a needle in there.

You're attached.

It's kinda hard to move.

With all standard therapies having failed Bo, Dr Fry and his team will be trying something

radical - re-engineering Bo's own immune system to cure his cancer.

The first step in that treatment is for Bo's T cells, a type of immune cell, to be removed

from his blood in a process called Apheresis.

Cells get separated in the machine into the different components.

The part that we need goes into a bag, the rest of it goes back into you in the other arm.

Does that make sense?

Yeah.

Sounds good.

Each leukemia cell in Bo's body is marked with different proteins on its surface.

Among them, one that is called CD22.

Since Bo's immune system doesn't recognize his leukemia is a threat, Dr Fry will genetically

modify one part of it, his T cells, so that they can recognize and attach themselves to

the CD22 protein and kill his cancer.

This modified T-Cell is called a Chimeric Antigen Receptor T-Cell, or CAR T-Cell for short.

It is at the cutting edge of cancer research and Bo will be the first leukemia patient

ever to receive the highest dose of these immune cells.

There's really no other option.

Without this working, Bo doesn't survive.

If this does not work for Bo, he's run out of time.

Finding a cure for cancer patients like Bo Cooper, who do not respond to standard treatment

is the holy grail of medical science and has proven to be one of the most difficult and

complicated questions facing humanity.

Nearly 40 years ago, right here at Building 10, one man began a personal quest for this

elusive cure.

Miraculously, he may have found the answer lurking within ourselves.

My voyage in this adventure, if you will, began when I was a junior resident in surgery

and a patient came in, a veteran in his 60s, with right upper quadrant pain.

It seemed to be a typical gall bladder attack.

But as I went through his chart, an astonishing story evolved.

12 years earlier, he had been operated on for a cancer that had started in his stomach.

The surgeons described it having spread to the liver and the patient's abdomen was closed,

nobody expected him to survive.

But as I flipped the pages of this chart, he was back in three months feeling okay.

Six months later he was gaining weight.

A year later, he was back at work.

And here he was 12 years later completely cancer free.

What Dr Rosenberg witnessed seemed impossible.

A person who cured himself of cancer.

Some how that patient's body had learned to destroy that cancer, had recognized it as

foreign, eliminated it just they way it eliminates a virus from a common cold.

It got me thinking that there must be something in that patient's body that caused the regression

and in fact the immune system is our major defense.

The idea that our own immune system is capable of fighting cancer was so radical that when

Dr Rosenberg began his research there wasn't even a name for this experimental treatment.

The main problem with your immune system recognizing cancer is that cancer, for the most part,

it really is self.

It's self gone bad.

So how do you tell your immune system that it's bad?

That's, that's the tough part.

For a decade, Dr Rosenberg tried to train the immune system to fight cancer in a number

of first In Human trials.

For years he failed.

But in 1985, he successfully cured his first patient with a treatment that has since become

known as Immunotherapy.

Activating the immune system for cancer treatment, so called Immunotherapy, is the most exciting

science in the whole cancer field because it's really working.

Today, Immunotherapy is the basis for many of the trials at Building 10, including the

one Bo Cooper is enrolled in.

You want to eat?

No.

You hardly ate anything.

In a Building 10 lab, Bo's immune cells are being genetically re-engineered in the hope

that they can recognize and fight his cancer.

Car T-Cells, that's what we're here for.

That's what we want.

Waiting is the hardest part.

Bo is scheduled to receive 200 million of these genetically modified immune cells.

But the work to create them in the lab is painstaking and can be unpredictable.

It's important for us to have a sense that, that process of making those Car T-Cells is

going to be successful.

I need to see as high of a number as they can possibly achieve.

The more cells the better.

What's the culture look like numbers wise?

This is today's?

Yeah, these are today.

Yeah, it dropped.

So you're read now at about 13% which isn't great.

The number of those cells is lower than I would have hoped for.

You know, so he may or may not need target dose, you know, but I mean, again, none of

this is certain until we see the final product next week, so...

We really can't wait before we treat him.

He clearly has progressive leukemia.

It's still early, it's gonna be low.

Yeah.

I mean there's something there.

The number of Car T-Cells that I have is not enough.

Dealing with these sorts of trials, it's a roller-coaster ride.

For more infomation >> First In Human EP1 (6/6) | What is a CAR T Cell? - Duration: 8:22.

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Miles Kwok : What is the mysterious no. 91 document ? When it will be released? 江泽民签署的神秘91号文件是什么？ - Duration: 4:01.

For more infomation >> Miles Kwok : What is the mysterious no. 91 document ? When it will be released? 江泽民签署的神秘91号文件是什么？ - Duration: 4:01.

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WHAT ARE SHOCK WAVES ? - Duration: 5:19.

0.95

0.96

0.98

0.99

What's that sound?

Do you know what that sound was?

Here's another video.

That was a plane creating a shock and breaking the sound barrier.

Recently, there have been a few of videos by Destin on smartereveryday where he talks

about bullets and whips producing shocks.

But what exactly is a shock?

Let's find out on today's episode.

Hi I'm Nikhilesh and I'm Kushal and we are the 2BrokeScientists

At the molecular level, fluid particles travel in a continuum.

When an obstruction is suddenly introduced into the flow, something interesting happens.

The particles in front of it slow down instantaneously, creating an increase in local pressure.

Since the fluid is a continuum, the information of whatever happens in one place is transmitted

to other regions in the form of pressure waves.

This pressure wave then causes the oncoming fluid to adjust its properties.

Don't these pressure waves remind you of something?

Doesn't sound also travel in the form of compressions and rarefactions through a medium?

The information propagation in a fluid happens through acoustic waves which travel at the

speed of sound.

What if the fluid particles are traveling faster than the speed of sound?.

Since the information transfer cannot happen faster than the speed of sound, these fast-moving

particles don't have any information about the obstruction in front until they actually

reach it.

The moment they reach it, an extreme collision of particles with themselves and the object

occurs which manifests itself as a shockwave.

A good analogy to information transfer in fluids are traffic waves.

Take a look at this busy roundabout where one of the cars suddenly slows down.

The driver behind this car receives information in the form of visual signals and he adjusts

his speed.

You can clearly see this wave of information passing backward even though the cars are

still moving forward.

If the cars were moving so fast that the drivers were not able to process the visual information,

they would then crash into each other.

That's exactly what happens in a shock wave.

You would have heard of the Mach number, a dimensionless number is very important while

studying shocks.

Mach number is basically the ratio of the velocity of a fluid to the velocity of sound

in that medium.

So clearly, if the Mach number is greater than 1, it means the fluid travels faster

than the speed of sound and there's no time for information to propagate.

These are called supersonic flows.

A moving shock is called a shock wave which is very thin somewhere in the order of 200

nm and in this region, the fluid undergoes sudden changes in properties.

The Mach number decreases across a shock wave along with a sudden rise in pressure, density

and temperature.

A shock wave is also an irreversible process because of the extreme reactions produced

by the collisions of the particles.

In some applications of aerospace engineering, we try to avoid shocks because they cause

vibrations and an increase in drag.

Even in commercial aircraft, while the plane itself might not go beyond M1, there are regions

over the wing where the flow can locally become supersonic.

This is the exact reason why most commercial planes have their wings swept back.

When air now flows over the wing, it sees a thinner wing because only a component of

the velocity is perpendicular to the wing and now does not accelerate to supersonic

speeds.

When a stationary object emits sound waves at a certain frequency, the waves are generally

spherical in nature and travel at the speed of sound.

The moment an object starts moving, the sound waves in front of the object compress increasing

the apparent frequency and the ones behind elongate decreasing the apparent frequency.

This is called the Doppler effect.

When the object travels faster than the speed of sound, the sound waves that are emitted

form a cone known as the Mach cone The thunderous clap that you heard at the beginning of the

video was when the camera enters the shock cone.

This phenomenon is what engineers took advantage of while designing stealth aircraft like the

SR 71 Blackbird, which travels at supersonic speeds.

By the time people on the ground heard the plane, it was well beyond the reach of missiles.

Shock waves produce a lot of changes in the properties of a fluid, but it's not always

easy to visualize change like pressure or density with our eyes.

That's where interesting visualization techniques like schlieren and shadowgraphy become useful.

Mediums with different densities have different refractive indices meaning that if light passes

through the medium, it changes direction.

We use this property of light to see all the cool images of shock waves.

If you want to build a schlieren setup at home, make sure to watch Derrick's video

at Veritasium.

So shockwaves aren't so shocking after all!!

Thanks for watching we hope you enjoyed the video.

If you have any suggestions dont forget to leave a comment below

And finally, don't forget to like share and subscribe

Bye

For more infomation >> WHAT ARE SHOCK WAVES ? - Duration: 5:19.

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🗡️Thử cắt tất cả bằng giấy-NTN/What can you cut with paper?🔪 - Duration: 15:44.

For more infomation >> 🗡️Thử cắt tất cả bằng giấy-NTN/What can you cut with paper?🔪 - Duration: 15:44.

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What really happened in 2018 - Duration: 8:35.

For more infomation >> What really happened in 2018 - Duration: 8:35.

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What happened in Finland? - MY DAY! (suomenkielinen video, english subs) - Duration: 6:42.

Good morning, greetings from Finland

I decided to film a Finnish vlog since I'm here in Finland

I'm currently staying at my parents' place at Nurmijärvi

I just woke up

As you can see. It's 9.30am

I'm walking our dog

He's also tired at mornings

He didn't wake up before this either

I'm filming this my day today

A day in Finland

Nothing special planned

I'm going to Hyvinkää at noon

Saying hi to my friend Aada and photgraphing her and her horse

And just talking about things

Besides that I'm just going to relax today

It's so beautiful because it's been humid and cold

The trees are covered in ice

I wish the sun would shine, then it would be perfect photo weather

But this will be ok

I hope it looks the same at Hyvinkää

You never know about the weather, but it looks promising right now

I'll take Snö with me, he'll be my assistant

I drove the wrong way twice

We got lost with Snö

But now we're finally here

I'll go looking for the barn door

And my dog is impatient because we've been driving around

He doesn't understand Finnish

Now we're on the photoshoot trip

The surroundings are so beautiful

A bit foggy, I love it

Maco (the horse) is excited

The photos will be great

Basic, every time when I photograph during winter my eyes water

But it's nice when there is snow, the pics will be great

We arrived at Hesburger (a hamburger restaurant)

It's a must every time I'm in Finland

We were at the barn with Aada and now it's time for FOOD

It's almost 4pm and I haven't eaten anything

-You haven't eaten anything?

Well I ate breakfast, but it's a while ago

I don't know what I should order

"Kerroshampurilainen" (layer burger) is the basic

cheese burger would be nice

- Layer burger and Hese's cucumber mayonaise is the thing

Aada knows

I don't know, I don't eat hamburgers or mayonaise

We just came back to my parent's house with Snö

Snö is exhausted from today

There were several girl dogs and Snö fell in love

And many other friends, and now he's tired

He fell asleep

I'm sitting in the guest room and have my robe on since I'm freezing

Going through the pics I took of Aada and Maco

I'm going to edit a few nice pics and publish them on social media

And then I'll make... What's it called in Finnish

Sample gallery

She can choose the photos

I took almost 400 photos and I've gone through them, now there's 253 left

Aada can choose the ones she like

I don't have the energy to choose them

So many of them

Rather give the model the option to choose the photos

I'll sit here about 30 min and fix these

Then it's time for dinner

My mum has made amazing food

What is this? Tell me

Stuffed pineapples, with shrimp, pineapple and nuts

Chicken, chicken and pork, all cooked with seasoning brought from Thailand

And here's coconut rice

It looks so delicious!

We've eaten delicous food and now it's time for sauna

Here's my sister

Sauna and jacuzzi

Here's the spa room

Snö is also going to sauna with us

Now we're in the jacuzzi, and you can't see anything

Wonderful! How cold is it?

39

About 0

No I mean outside temperature

It's about 0 degrees outside and the jacuzzi is 39 (celsius)

It's perfect

It's perfect to end a nice day here

bye bye

Where are you

For more infomation >> What happened in Finland? - MY DAY! (suomenkielinen video, english subs) - Duration: 6:42.

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WHAT TO DO IN FINLAND'S LAKELAND in 60 seconds - Duration: 1:14.

What to do in Finland. The Lakeland in 60 seconds!

Europe's largest lake district is a stunner.

And you can explore it in many different ways.

Let the captain do the work

or give yourself a workout. Literally a "ridge" experience.

Because it's a ridge!

And then reward yourself with mushrooms

and berries.

They even make berry wine!

(sings) O-hoo summer wine!

Make yourself delicious pies

and your own Finnish knife.

No wonder Lakeland is Santa's summer hideaway. Hoho!

Travel back in time. On a boat

to a medieval castle

or by dancing the night away.

The Lakeland makes you dizzy in a good way. (screams)

Create your own instrument of torture,

work up another sweat,

have one last drink

and float asleep.

For more infomation >> WHAT TO DO IN FINLAND'S LAKELAND in 60 seconds - Duration: 1:14.

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Welcome To My Channel Intro - Description of What To Expect From Life Gains Fitness and Health - Duration: 4:06.

what are we going to all be about on the life game Fitness channel well I'm going

to tell you in this video and if you're finding me for the first time thank you

for coming please subscribe to this channel so that you don't miss out on

any of the content we put out let's go

what's good everybody you're in the building with y'all knowing or loving

all feeling I'm seeing all powerful just damn all everything the sex is hell host

and we are talking about fitness this is my intro video to all you all who have

come here that have followed me from my big channel because you want to hear

about my fitness exploits and this channel is gonna be all about fitness

healthy lifestyle supplementation making a fitness journey all getting yourself

in better health because in my opinion good health equals wealth and quality of

life and that's what we call life gains some of you all may not be familiar with

my fitness journey I started out a very very heavy kid I mean I was asthmatic

which preempted my mom to do behaviors that caused me to be heavy from the jump

I popped out my mom a 112 pounds and just kept expanding by sixth grade I was

200 pounds with bad behaviors no working out asthmatic which didn't help anything

but along the way for all these years of learning got with great coaches did a

lot of studying and I finally got my fitness under control got my weight down

from the heaviest I was was 350 I got all the way down to a nice and clean one

eighty five nine percent body fat and have gone and kind of stayed around that

direction my whole entire life some things that are going to be

important that we're going to talk about in this channel other than just fitness

journeys its debunking myths I hate snake oil I hate people that say

one thing promote a product and it's really not doing what it does you're

gonna see a whole lot of that in the fitness industry people that I'll tell

you they are using CBD oil they'll tell you they are using this supplement that

supplement to get their gains when they are totally using something else and

it's a lie we're going to use science-based information to let you

guys know what really works what doesn't what's achievable for someone who's

natural versus someone who's used in performance enhancers we're going to

talk about all that we're going to talk about what's going on in the world of

bodybuilding what's going on in the medical world

no my wife is a nephrologist and adopter who deals with people that have

hypertension and kidney problems her link is in the video description as well

if you want to expand a little more on that subscribe to her channel also but

at the end of the day we are here to try to help you guys make those physical

gains in fitness and in health so what you ultimately live a long polity of

life which we call life games on this channel and if you want to get with me

for one-on-one consulting for training anything building you a plan check the

video description for a one-on-one consulting join my email list I try to

call a couple of people each and every month that join that list is absolutely

free to join that list but if you want that one-on-one consulting check the

plan in the video description and let's see if we can all make these life games

together and that's what this channel is all

about that's gonna do it for this video don't forget to like this video comment

and subscribe go get yourself a life game hit your boy up if you need help

getting on that fitness track with proven information proven data and a

person who's used this data on himself to achieve a little bit of cuts for the

sluts and until that net sex is hell video I'll see you

you

For more infomation >> Welcome To My Channel Intro - Description of What To Expect From Life Gains Fitness and Health - Duration: 4:06.

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INDO ENG SUB Saintsup - What's in your bag - Duration: 5:51.

For more infomation >> INDO ENG SUB Saintsup - What's in your bag - Duration: 5:51.

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WHAT DO YOU WANT TO SAY TO THE WORLD? - Kerry , 33 (Legendas disponíveis) - Duration: 8:00.

For more infomation >> WHAT DO YOU WANT TO SAY TO THE WORLD? - Kerry , 33 (Legendas disponíveis) - Duration: 8:00.

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What will patients get out of the NHS Long Term Plan? - Duration: 2:40.

For more infomation >> What will patients get out of the NHS Long Term Plan? - Duration: 2:40.

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Man Behind 'What The Buck' Lands In Denver In Renewed YouTube Venture - Duration: 2:09.

For more infomation >> Man Behind 'What The Buck' Lands In Denver In Renewed YouTube Venture - Duration: 2:09.

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What is the hard problem of consciousness? | Rupert Sheldrake in under 60 seconds - Duration: 1:05.

For more infomation >> What is the hard problem of consciousness? | Rupert Sheldrake in under 60 seconds - Duration: 1:05.

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NCT 127 엔시티 127 'Simon Says' MV Reaction!! | WHAT MASKS ARE THOSE?!! [ENG SUB] - Duration: 6:23.

For more infomation >> NCT 127 엔시티 127 'Simon Says' MV Reaction!! | WHAT MASKS ARE THOSE?!! [ENG SUB] - Duration: 6:23.

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What happens when we want to jump ... Brain Body Coordination (Eng Subs) - Duration: 0:44.

Hello Kids today let's talk about how to jump

Our brain sends signals to our muscles making them move

After that, our muscles pull the bone and then our knees bend and stretch making us jump

Bye Bye kids

See you later, now I am going to go for more facts

Jumping Jacks, Jumping Jacks

For more infomation >> What happens when we want to jump ... Brain Body Coordination (Eng Subs) - Duration: 0:44.

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What item would make your life so much easier? - Duration: 4:48.

hello friends I am dragonate and welcome to another dragonate reading your answers

video last week I asked you what your new year's resolution was you guys

answered and I'll be reading your answers in this video but before we get

started we need a new one for this week and mm-hmm

I always forget to think of one so give me a minute

mm-hmm what item would make your life much easier right now that is your

question now this item has to be an actual existing item not something like

a teleporting device or something you can't just make something up it can't be

something that's theoretical or non-existent has to be something that

actually exists so what item would make your life much easier right now leave

your answers in the comments below and I'll read them next week now also before

we continue uh let me know what you think of the video now ignore the

background everything that I'm being lazy with the green screen but in terms

of quality of the video I have this now set to 60fps but the problem is the

resolution has to of the camera has to be at 720 for that to work instead of

1920 but I blowing it up to 1920 10 1080 out of goodness gracious video you're

watching 1080p for me to have 60fps camera resolution has to be 720p so 720

blown up to 1080 let me know what you think about that it might look a little

bit blurry or pixelated it's a 60fps feel smoother and now let's read your

answers for this week starting with Rhonda who says at my age I gave up on

resolutions many moons ago sorry you lost your job Nathan hope you pray I'm

sorry I hope and pray you find an awesome job as a new year along with

hope and pray that your mom's health gets better and can be healed take care

love you and hugs let me do thank you and yeah about the job thing don't worry

about it too much I'll figure that out I guess at some point my mom says I don't

make resolutions for the new year but I do hope and pray for healing of my MS

this year new this is new year ghost talk says I don't think I really have a

new year's resolution I remember watching a video from Jo it's a day or

two ago mentioning the idea making resolution and by the

end of a year after that a new year begins I think at most I don't really

like New Year's resolutions and I never had I remembered school I had to write

out what mine was when in reality I just wrote wrote anything that come into mind

that wasn't a New Year's resolution the only thing I wish to happen is just to

make it to United States with my family so we can live long and prosper

Star Trek reservoir reference well I guess I gave emojis in my reply and this

is what the motives were but I don't think they showed up because I showed up

as boxes and meets who says tonight I did this New Year's was last Sunday

night tours for me it was Monday night but she already burned a couple sizzling

star beam sticks or sizzling sizzling sizzling as we call them in Finland I

never really do resolutions with my goal for the new for the coming years to

survive my first end of writing a K finals well good luck with that I'm sure

you'll do well Coco does this for some reason because

he's a but and Omar says I really really I hope I really really really hope I

don't want to be a troublemaker in high school I want to open a new page in my

life I want to forget my old life and open a new page in my life starting from

high school still need to finish this year I'm I'm a ninth grader so yeah I

wish Ben good luck don't worry I'm sure you'll do fine in doing that you just

gotta change it I guess not too much else to really say regarding that just

you can do it though and that is it and for my new year's resolution or whatever

I don't I know I don't really care too much about the the resolution stuff

either I just I guess I said resolution because that's kind of the resolutions

are at the traditional thing so but my goal for this year is a couple things

one to read a little more because last year I the beginning of the year

actually I was reading a bit not a lot but a bit and I stopped halfway through

or something for some reason and part two is to be a little bit less lazy and

to catch up on things and I'm Way behind on so yeah we'll see how well that goes

hopefully hopefully pretty well that's it thank you all so much for watching I

hope you enjoyed this video again let me know about the resolution thing is a to

Pixley to whatever or do you like how I usually do it the other way also don't

forget your question which is the what item would make your

life so much easier right now leave your answers in the comments below and I'll

read them next week that's it I hope you all had a great start to the new year it

seems like it so far um and all the best I wish you all the best for 2019 see you

again real soon have a wonderful day bye bye and Godbless